PHILADELPHIA — Donald Trump is aiming for a sweep of all five Northeastern states holding primaries Tuesday, including Pennsylvania, with his rivals pinning their hopes of stopping the Republican front-runner on a fragile coordination strategy in the next rounds of voting.

For Democratic leader Hillary Clinton, wins in most of Tuesday’s contests would leave little doubt that she’ll be her party’s nominee. Rival Bernie Sanders’ team has sent mixed signals about his standing in the race, with one top adviser suggesting a tough night would push the Vermont senator to reassess his bid and another vowing to fight “all the way to the convention.”

Clinton was already looking past Sanders, barely mentioning him during recent campaign events. Instead, she deepened her attacks on Trump, casting the billionaire businessman as out of touch with Americans.

“If you want to be president of the United States, you’ve got to get familiar with the United States,” Clinton said. “Don’t just fly that big jet in and land it and go make a big speech and insult everybody you can think of.”

Asked Monday whether she needed to do more to gain Sanders’ support in the general election, she noted her loss in the 2008 Democratic primaries to Barack Obama.

“I did not put down conditions,” she said on MSNBC. “I said I am supporting Senator Obama. … I hope that we will see the same this year.”

In addition to Pennsylvania, Connecticut, Delaware, Maryland and Rhode Island hold primaries on Tuesday. Candidates and outside groups have spent $13.9 million dollars on advertisements in the states, with Clinton and Sanders dominating the spending.

Sanders said candidly on ABC’s “Good Morning America” that his campaign is “handicapped” since the states in play Tuesday don’t allow independents to participate, but added that “we are going to fight through California and then we’ll see what happens.”

Democrats are competing for 384 delegates in Tuesday’s contests, while Republicans have 172 up for grabs.

The Democratic race is far more settled than the chaotic GOP contest, despite Trump having a lead in the delegate count. The businessman is the only one left in the race who can reach the 1,237 delegates needed to clinch the nomination before the convention, but he could very well fall short, pushing the nominating process to the party’s July gathering in Cleveland.

Texas Sen. Ted Cruz and Ohio Gov. John Kasich are now joining forces to try to make that happen. Their loose alliance marks a stunning shift in particular for Cruz, who has called on Kasich to drop out of the race and has confidently touted the strength of his convention strategy.

Kasich has won just a single primary — his home state — but hopes to sway convention delegates that he’s the only Republican capable of defeating Clinton in the general election.

Under their new arrangement, Kasich won’t compete for votes in Indiana, allowing Cruz to take Trump on head to head in the state’s May 3 primary. Cruz will do the same for Kasich in Oregon and New Mexico.