FLINT, Mich. — Hillary Clinton and Bernie Sanders tangled aggressively on economic issues in a Democratic presidential debate over trade, Wall Street influence and more.

Clinton accused him of turning his back on the auto industry and Sanders countered in the Sunday night debate that Clinton’s friends on Wall Street had “destroyed this economy.”

It was a marked change in tone for the two Democrats, signaling Sanders’ increasingly difficult effort to slow the momentum of the party’s front-runner. Both candidates frequently interrupted one another and accused each other of misrepresenting their records.

“Let’s have some facts instead of some rhetoric for a change,” Clinton snapped at Sanders at one point.

“Let me tell my story, you tell yours,” Sanders shot back at another. “Your story is voting for every disastrous trade amendment and voting for corporate America.”

More than once, Sanders chafed at Clinton’s interruptions, saying, “Excuse me, I’m talking” or “Let me finish, please.”

Their disagreements were clear, but still the debate’s tone was nothing like that of the Republican debate in Detroit just three days earlier, a four-way faceoff that was marked by a steady stream of personal attacks, insults and even sexual innuendo. The Democrats’ faceoff, in comparison, was a more civil, if heated, affair.

Clinton said that while she and Sanders have their differences on policy, “compare the substance of this debate with what you saw on the Republican stage last week.”

Sanders chimed in, “We are, if elected president, going to invest a lot of money into mental health and when you watch these Republican debates you know why.”