CHINCOTEAGUE, Va. — Crews searched for scorched wreckage along the Virginia coast Wednesday in hopes of figuring out why an unmanned commercial rocket exploded in a blow to NASA’s strategy of using private companies to fly supplies and, eventually, astronauts to the International Space Station.

The 140-foot Antares rocket, operated by Orbital Sciences Corp., blew up 15 seconds after lifting off for the space station Tuesday, lighting up the night sky and raining flaming debris on the launch site. No one was injured, but the $200 million-plus mission was a total loss.

The blast not only incinerated the cargo — 2½ tons of space station food, clothes, equipment and science experiments dreamed up by schoolchildren — but dealt a setback to the commercial spaceflight effort championed by NASA and the White House even before the shuttle was retired.

It was the first failure after an unbroken string of successful commercial cargo flights to the space station since 2012 — three by Orbital and five by SpaceX, the other U.S. company hired by NASA to deliver supplies.

Although the cause of the blast is still unknown, several outside experts cast suspicion on the 1960s-era Russian-built engines used in the rocket’s first stage. Orbital Sciences chairman David Thompson himself said the Russian engines had presented “some serious technical and supply challenges in the past.”

He said he expects the investigation to zero in on the cause within a week or so. The launch pad on Wallops Island appeared to have been spared major damage.

As for launching again, Thompson said he expects a delay of at least three months in the company’s next flight to the space station, which had been set for April.

“We are certainly disappointed by this failure, but in no way are we discouraged or dissuaded from our objectives,” he told investors in a phone conference.

Former NASA Administrator Michael Griffin, who helped spearhead the commercial cargo effort, noted that the Antares rocket was still in development. He and others associated with the space agency went into the program knowing that failures were likely.

“It’s obviously tragic and upsetting, but we’ll move on,” Griffin told The Associated Press.

In another few years, NASA hopes to launch astronauts again from U.S. soil — aboard commercially supplied spacecraft.

Orbital Sciences has never intended to fly anything more for NASA than cargo. The political fallout from the blast is more likely to affect SpaceX and Boeing, both of which are under NASA contract to fly Americans to the space station by 2017.

“We can’t allow the one incident of the Antares vehicle loss to smear space commercialization in Washington and on the Hill,” Boston-based space analyst Charles Lurio said in an email.